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From the synthetic point of view, three-membered ring products are very important due to their wide applications as synthetic intermediates and their frequent occurrence as structural subunits in biologically active natural/unnatural products. Readership: Graduate students and researchers who are engaged in or have interest in the chemistry of diazo compounds.Īlong with carbene C–H bond insertions, cyclopropanations with unsaturated bonds through metal carbene represent the characteristic transformations of diazo compounds with transition metal catalysts (Scheme 4.1). Application of Diazo Compounds in the Synthesis of Natural Products.Transition-Metal-Catalyzed Cross-Coupling with Diazo Compounds.Reactions with Diazo Compounds as Nucleophiles or Electrophiles.Diazo Compounds as 1,3-Dipoles in Cycloadditions.Olefination with Diazocarbonyl Compounds.Wolff Rearrangement and Related 1,2-Shift Reactions.Development of New Catalysts for Metal Carbene Transformations.New Developments in the Synthesis of Diazo Compounds.The authors aim to provide a contemporary and comprehensive review for investigators engaged in or with interest in diazo compounds to boost further developments in this fascinating field. They also cover the application of flow chemistry in diazo reactions.

In this comprehensive book, the authors cover the most recent advances in the fields related to diazo compounds, including the application of donor-acceptor carbenes, carbene-based cross-coupling reactions and polymerizations, as well as the breakthrough in catalytic asymmetric carbene O-H, S-H, and N-H bond insertions.

In addition to organic synthesis, diazo compounds have found applications in interdisciplinary fields such as material sciences, chemical biology and also polymerization. Over the past twenty years, there have been over fifty reviews and accounts related to the reactions of diazo compounds, but most of them cover limited aspects of diazo compounds. Studies of diazo compounds have been ongoing for a very long time but still attract significant attention within the organic chemistry community, with new papers related to diazo compounds appearing at a daily pace. Diazo compounds are versatile substances with diverse transformations in organic synthesis and other fields.